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中国科学院青岛能源所等揭示CAST基因编辑系统的内源转录调控机制(图)
青岛能源 CAST基因编辑 转录调控
2023/3/15
CRISPR-Cas基因编辑技术是颇具影响力的创新技术。当前已开发的CRISPR-Cas基因编辑工具多依赖于靶点DNA双链切割,并需要借助宿主自身的同源重组或者非同源末端连接DNA修复系统实现基因编辑,而脱靶效应和编辑效率低是瓶颈,阻碍了该技术在人类疾病治疗等领域的应用。开发更高效精准的且无需DNA双链断裂的基因编辑工具是这一领域亟待解决的科学问题。
Association of CAST Gene Polymorphisms with Carcass and Meat Quality Traits in Chinese Commercial Cattle Herds
Calpastatin Gene Carcass and Meat Quality Traits Beef Cattle SNPs
2016/5/5
Calpastatin (CAST), an endogenous inhibitor of the calpains, plays an important role in post-mortem tenderization of meat. The objectives of this study were to investigate single nucleotide polymorphi...