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中国生物物理学会陈畅组与万一组揭示NO抑制铜绿假单胞菌的新机制（图）
铜绿假单胞菌 绿脓杆菌 抗生素 藻酸盐
2022/9/15
铜绿假单胞菌（PA）别名绿脓杆菌，占全球的院内感染的10%~15% ，铜绿假单胞菌的感染致死率高达约38%，目前的治疗方案主要集中在抗生素治疗，产生耐药性是治疗方案所要面临的挑战。如何有效抑制铜绿假单胞菌及减少其对抗生素的耐药性是临床治疗中的关键难题。针对此科学问题，中国科学院生物物理研究所陈畅研究员与陕西省微生物研究所万一研究员开展合作研究，于2022年8月17日在 Nitric Oxide 杂...
在囊性纤维化（CF）患者感染过程中，铜绿假单胞菌（PA）易转化为粘液型菌株，其特点是过度产生藻酸盐。藻酸盐在胞外形成的粘液层，导致病人呼吸困难，并产生抗药性。陕西省微生物研究所万一研究员课题组与中国科学院生物物理所陈畅研究员课题组开展合作研究，于2022年8月23日在《Nitric Oxide》（IF 4.898）杂志发表了题为" Nitric oxide inhibits alginate b...
在囊性纤维化（CF）患者感染过程中，铜绿假单胞菌（PA）易转化为粘液型菌株，其特点是过度产生藻酸盐。藻酸盐在胞外形成的粘液层，导致病人呼吸困难，并产生抗药性。陕西省微生物研究所万一研究员课题组与中国科学院生物物理所陈畅研究员课题组开展合作研究，于2022年8月23日在《Nitric Oxide》（IF 4.898）杂志发表了题为" Nitric oxide inhibits alginate b...
以绿豆幼苗为材料，研究了外源一氧化氮（NO）处理对Cd2+胁迫3天和8天时幼苗叶片和根系DNA含量、DNA链间交联程度以及叶片光合参数的影响。结果表明：单独Cd2+胁迫导致叶片和根系DNA含量降低，DNA链间交联程度增加，叶片净光合速率、气孔导度和胞间隙CO2浓度降低，气孔限制值升高；与单独Cd2+胁迫相比，NO和Cd2+复合处理提高了叶片和根系DNA含量，降低了DNA链间交联程度，同时使叶片净光...
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men
mustard allyl-isothiocyanate energy expenditure thermogenesis thermogenic food
2018/11/20
Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates t...
UMass Amherst Study of Bee Health Finds No Natural Medicine in Once-Promising Compound
UMass Amherst Study Bee Health No Natural Medicine Once-Promising Compound
2017/9/5
A new study of possible self-medicating behavior in bumble bees conducted by researchers at the University of Massachusetts Amherst reports that a once-promising finding was not supported by further e...
外源NO对野生早熟禾幼苗抗寒性的影响
一氧化氮 低温胁迫 渗透调节 保护酶
2018/4/18
以野生草地早熟禾（Poa pratensis）和硬质早熟禾（Poa sphondylodes）为材料，通过人工室内模拟低温逆境胁迫，研究外源一氧化氮（NO）供体亚硝基铁氰化钠（硝普钠，SNP）对低温胁迫下野生早熟禾幼苗生长、渗透调节和抗氧化系统的影响，探讨外源NO提高早熟禾抗寒性的生理机制。结果表明，低温胁迫下：0~700 μmol·L-1浓度范围内，随SNP浓度的增大，两个供试材料的地上生物量和...
Breakfast consumption has no effect on neuropsychological functioning in children: a repeated-measures clinical trial
breakfast consumption breakfast skipping cognition neuropsychological functioning children
2018/12/14
Background: Although many studies have investigated the relation between breakfast consumption and various domains of cognitive functioning within children, some of the reported findings are inconsist...
Ultrafast Measurements of Geminate Recombination of NO with Site-specific Mutants of Human Myoglobin
human myoglobin mutagenesis kinetics structure-function relationships picosecond timescale
2016/5/23
Flash photolysis studies of NO recombination to heme proteins offer a direct probe of protein structural changes on the tens of picoseconds timescale where they can be compared with molecular dynamics...
Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health
bone density bone turnover half-life obesity vitamin D vitamin D–binding protein
2018/11/30
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D–binding proteins (DBPs) ...
Early Human Habitat,Recreated for First Time,Shows Life Was No Picnic
Early Human Habitat Life Was No Picnic
2016/3/21
Scientists have pieced together an early human habitat for the first time, and life was no picnic 1.8 million years ago.Our human ancestors, who looked like a cross between apes and modern humans, had...
Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial
blood glucose GLP-1 HbA1c incretin resveratrol
2018/11/23
Background: Resveratrol has been reported to lower glycemia in rodent models of type 2 diabetes associated with the stimulation of glucagon-like peptide 1 (GLP-1), which is known to slow gastric empty...
In the animal kingdom, the battle of the sexes often truly becomes a battle. Among chimpanzees, males may violently attack females, sometimes resulting in serious wounds. While unpleasant to watch, th...
Durham, NC - No single “one-size-fits-all” model can explain how biodiversity hotspots come to be, finds a study of more than 700 species of reptiles and amphibians on the African island of Madagascar...