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MIT neuroscientists have found a way to reverse neurodegeneration and other symptoms of Alzheimer’s disease by interfering with an enzyme that is typically overactive in the brains of Alzheimer’s pati...
Combining state-of-the-art X-ray technology and cryogenics, Cornell physics researchers have developed a new method for analyzing proteins in action, a breakthrough that will enable the study of far m...
Duchenne muscular dystrophy (DMD), a rare genetic disease usually diagnosed in young boys, gradually weakens muscles across the body until the heart or lungs fail. Symptoms often show up by age 5; as ...
Chemists Get Step Closer to Replicating Nature with Assembly of New 3D Structures（图）
chemists step closer replicating nature new 3d structures
2017/9/5
A team of New York University chemists has created a series of three-dimensional structures that take a step closer to resembling those found in nature. The work offers insights into how enzymes are p...
Keeping the human brain in a healthy state requires a delicate balance between the generation of new cellular material and the destruction of old. Specialized structures known as lysosomes, found in n...
Scientists identify two new proteins connected to plant development
Scientists two new proteins connected plant development
2017/7/20
The discovery of two new proteins could lead to better ways to regulate plant structure and the ability to resist crop stresses such as drought, thus improving agriculture productivity, according...
Rice University scientists have learned to spy on cells with a divide-and-conquer strategy to label proteins.Graduate student Emily Thomas, synthetic biologist Jonathan Silberg and their colleagues bu...
JILA Team Discovers Many New Twists in Protein Folding
JILA Team Many New Twists Protein Folding
2017/3/14
Biophysicists at JILA have measured protein folding in more detail than ever before, revealing behavior that is surprisingly more complex than previously known. The results suggest that, until now, mu...
Old enzyme,new role
Old enzyme new role
2017/2/16
A team of researchers at the University of Delaware has discovered a new function for an enzyme that has long been known to have a central role in bacterial metabolism.Maciek Antoniewicz, Centennial J...
Researchers in the UO lab of chemist Michael Pluth are part of a global battle against oxidative stress in the human body. It happens as we age and when we eat too much, smoke and drink alco...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:1.New Inhibitors and Vibrational Stark Effect Measurements
apoptosis ATM cisplatin IKK p73 ubiquitination
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new hALR2 inhibitor was designed and sy...
Discovery of New Ligand Binding Pathways in Myoglobin by Random Mutagenesis
Animals Whales Myoglobin Ligands Genetic Techniques Mutagenesis Binding Sites Amino Acid Sequence Protein Conformation Structure-Activity Relationship
2016/5/23
A random library of single amino acid mutants of myoglobin was generated using a highly efficient, single-base-misincorporation random mutagenesis method to discover new ligand-binding pathways in myo...
New Class of Molecular ‘Lightbulbs’ Illuminate MRI
New Class of Molecular Lightbulbs Illuminate MRI
2016/4/13
Duke University researchers have taken a major step towards realizing a new form of MRI that could record biochemical reactions in the body as they happen.In the March 25 issue of Science Advances, th...
近日，第251届ACS National Meeting在美国圣地亚哥召开。我院陈兴研究员获得了2016年David Y. Gin New Investigator Award，并作获奖报告，介绍了其课题组近年来在聚糖选择性标记与成像方向上的研究工作。
New trigger for self-powered mechanical movement（图）
New trigger self-powered mechanical movement
2016/3/2
A new way to use the chemical reactions of certain enzymes to trigger self-powered mechanical movement has been developed by a team of researchers at Penn State University and the University of Pittsb...