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19F NMR of Trifluoroacetyl-Labeled Cysteine Mutants of Myoglobin:Structural Probes of Nitric Oxide Bound to the H93G Cavity Mutant
19F NMR Trifluoroacetyl Cysteine Mutants Myoglobin Nitric Oxide H93G Cavity Mutant
2016/5/23
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...
Structural changes between signaling states of bacterial chemoreceptors probed by solid -state NMR and hydrogen exchange
Structure of membrane protein lipid environment membrane signals bacteria chemical sensors membrane domains solid-state nuclear magnetic resonance (NMR)
2014/12/11
The limitations of structural studies of membrane proteins imposed by the lipid environment has made it difficult to determine the molecular mechanism of transmembrane signaling. For the bacterial che...
摘要 用2D NMR深入研究了五肽、四肽胃泌素在 DMSO 中的构象。利用 COSY 谱、Relayed-COSY 谱、DQF-J 分解谱和 NOESY 谱归属了全部共振峰。计算了肽键平面的Φ角、旋转异构体分布和旋转异构体之间自由能差。根据 NOESY 谱得到了距离约束条件。结合Φ角及旋转异构体分布, 推导出五肽胃泌素分子的构象膜型。结果表明, 五肽、四肽胃泌素在 DMSO 中以半角构象存在, 在...
摘要 Asterin B和C是从紫菀中分得的两个寡肽, 本文利用2D-NMR技术归属了它们的^1H NMR谱线, 并讨论了它们的构象特征。为进一步采用NMR和分子动力学(MD)方法研究它们的溶液构象奠定了基础。